Description

5-Chloro-2,4-Difluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its unique halogenated aromatic structure, which is essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro substituents contribute to target specificity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated organic semiconductors, liquid crystal compounds, and electron-transport materials in display and lighting technologies.
• Chemical Biology & Proteomics: Employed as a photoaffinity labeling agent or a core structure for designing activity-based probes to study enzyme mechanisms and protein interactions.
• Polymer Modification: Incorporated into polymer backbones or as a pendant group to impart specific properties like UV stability, altered refractive index, or specialized surface characteristics.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and conjugated systems.

Basic Information

Product Name	5-Chloro-2,4-Difluorocinnamic Acid
CAS No.	695187-30-5
Molecular Formula	C9H5ClF2O2
Molecular Weight	218.59 g/mol
Synonyms	(2E)-3-(5-Chloro-2,4-difluorophenyl)prop-2-enoic acid; 5-Chloro-2,4-difluorocinnamic acid; trans-5-Chloro-2,4-difluorocinnamic acid; (E)-3-(5-Chloro-2,4-difluorophenyl)acrylic acid; 3-(5-Chloro-2,4-difluorophenyl)-2-propenoic acid; 5-Chloro-2,4-difluorocinammic acid; Cinnamic acid, 5-chloro-2,4-difluoro-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Difluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.