Description

2,4,5-Trifluorocinnamic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the trifluoromethylphenyl moiety imparts desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in advanced display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for efficient OLED devices.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for amide bond formation, useful in creating fluorinated peptide analogs or linker molecules.
• Academic & Industrial Research: A valuable reagent for method development and exploring new fluorination chemistry in R&D settings.
• Material Science Additive: Incorporated into polymers to modify thermal stability, solubility, and surface properties.

Basic Information

Product Name	2,4,5-Trifluorocinnamic Acid
CAS No.	694511-56-3
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(E)-3-(2,4,5-Trifluorophenyl)acrylic acid; 2,4,5-Trifluorocinnamic acid; trans-2,4,5-Trifluorocinnamic acid; 3-(2,4,5-Trifluorophenyl)-2-propenoic acid; (2E)-3-(2,4,5-Trifluorophenyl)prop-2-enoic acid; α,2,4,5-Tetrafluorocinnamic acid (incorrect but common alias); 2,4,5-Trifluoro-trans-cinnamic acid
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.