Description

Dasotraline is a selective and potent dual dopamine and norepinephrine reuptake inhibitor (DNRI) with a long half-life, offering a distinct pharmacological profile. This compound is of significant interest for research into central nervous system (CNS) disorders and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D organizations, academic research institutions, and contract research organizations (CROs) focused on neuropharmacology and drug discovery.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Neuropharmacology Research: Used in preclinical studies to investigate the mechanisms of dopamine and norepinephrine reuptake inhibition and its effects on animal models.
• Drug Discovery & Development: Acts as a key intermediate or active pharmaceutical ingredient (API) in the synthesis and development of new CNS-targeting therapeutics.
• Biochemical Assays: Employed in in vitro studies to screen for biological activity and assess binding affinity at relevant neurotransmitter transporters.
• Metabolic and Pharmacokinetic Studies: Utilized to study the absorption, distribution, metabolism, and excretion (ADME) profiles of DNRIs.

Basic Information

Product Name	Dasotraline
CAS No.	675126-05-3
Molecular Formula	C17H19NO
Molecular Weight	253.34 g/mol
Synonyms	(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine; SEP-225289; SEP 225289; SEP225289; Dasotraline Hydrochloride (salt form precursor)
EINECS	Contact for details

Quality Control

Our Dasotraline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under inert atmosphere when handling to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.