Description

5-Bromo-2,4-Difluoro-3-(Triethylsilyl)Benzoic Acid is a high-value, multi-functional organosilicon building block characterized by its unique halogenated and silyl-protected aromatic structure. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules where precise steric and electronic control is required. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Protecting Group Strategy: The triethylsilyl (TES) group acts as a robust protecting group for the carboxylic acid, allowing for selective functionalization at other sites on the aromatic ring.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms of action.

Basic Information

Product Name	5-Bromo-2,4-Difluoro-3-(Triethylsilyl)Benzoic Acid
CAS No.	651027-08-6
Molecular Formula	C15H21BrF2O2Si
Molecular Weight	379.32 g/mol
Synonyms	3-(Triethylsilyl)-5-bromo-2,4-difluorobenzoic acid; Benzoic acid, 5-bromo-2,4-difluoro-3-(triethylsilyl)-; 5-Bromo-2,4-difluoro-3-triethylsilylbenzoic acid; 651027-08-6; TES-protected 5-bromo-2,4-difluorobenzoic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Difluoro-3-(Triethylsilyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.