Description

Methyl 2-Chloro-5-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This intermediate is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals where the introduction of halogenated benzoate motifs is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitution reactions to introduce functionalized benzoate groups into larger molecular architectures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	Methyl 2-Chloro-5-Fluorobenzoate
CAS No.	647020-63-1
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-Chloro-5-fluorobenzoic acid methyl ester; Methyl 2-chloro-5-fluorobenzoate; Benzoic acid, 2-chloro-5-fluoro-, methyl ester; 5-Fluoro-2-chlorobenzoic acid methyl ester; Methyl 5-fluoro-2-chlorobenzoate; 2-Chloro-5-fluorobenzoic acid, methyl ester; Methyl o-chloro-p-fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-5-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at controlled room temperature for shorter periods. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.