Description

3-(β-D-2-Deoxyfuranosyl)-6-Methyl-5'-Dimethoxytrityl-Pyrrolo-[2,3-D]-Pyrimidin-2-One is a sophisticated nucleoside analog building block, a critical intermediate in the synthesis of modified oligonucleotides. Its value lies in enabling precise genetic research and therapeutic development by allowing the controlled introduction of specific modifications into nucleic acid sequences. This high-purity compound is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on antisense technology, siRNA, and diagnostic probe development.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Drug Development: Used to create research-grade and therapeutic oligonucleotides with enhanced stability and binding affinity.
• Diagnostic Probe Manufacturing: Incorporated into fluorescent probes and primers for advanced molecular diagnostics and PCR applications.
• Structural Biology Studies: Serves as a tool to investigate nucleic acid structure, function, and protein interactions.
• Academic & Pharmaceutical R&D: A fundamental reagent for exploring novel genetic targets and therapeutic modalities.

Basic Information

Product Name	3-(β-D-2-Deoxyfuranosyl)-6-Methyl-5'-Dimethoxytrityl-Pyrrolo-[2,3-D]-Pyrimidin-2-One
CAS No.	644962-87-8
Molecular Formula	C35H35N3O6
Molecular Weight	593.68 g/mol
Synonyms	6-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-pyrrolo[2,3-d]pyrimidin-2-one; 5'-O-DMT-6-methyl-2'-deoxy-pyrrolo[2,3-d]pyrimidin-2-one riboside; DMT-6-Me-dP* (common abbreviation); Pyrrolo[2,3-d]pyrimidine nucleoside intermediate; 2'-Deoxy-6-methylpyrrolo[2,3-d]pyrimidin-2-one DMT protected; 6-Methyl-2'-deoxy-pyrrolo-dC DMT derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for pharmaceutical research. Every batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.