Description

5-(4-Fluoro-Phenyl)-Isoxazole-4-Carboxylic Acid is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique isoxazole core and carboxylic acid functionality enable precise molecular design. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the fluorinated isoxazole moiety.
• Material Science Research: Serves as a building block for creating novel organic ligands, polymers, and functional materials with specific electronic or photophysical properties.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-(4-Fluoro-Phenyl)-Isoxazole-4-Carboxylic Acid
CAS No.	618383-51-0
Molecular Formula	C10H6FNO3
Molecular Weight	207.16 g/mol
Synonyms	5-(4-Fluorophenyl)-1,2-oxazole-4-carboxylic acid; 5-(p-Fluorophenyl)isoxazole-4-carboxylic acid; 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-; 5-(4-Fluorophenyl)-4-isoxazolecarboxylic acid; 618383-51-0; 5-(4-Fluorophenyl)isoxazole-4-carboxylic acid; 5-(4-Fluorophenyl)-4-carboxyisoxazole
EINECS	Contact for details

Quality Control

Our 5-(4-Fluoro-Phenyl)-Isoxazole-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and production. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.