Description

Methyl A,G-Dioxo-4-Trifluoromethylbenzenebutanoate is a high-purity, specialized organic intermediate featuring a trifluoromethylphenyl and a butanoate ester backbone. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where the introduction of the trifluoromethyl group is key for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Advanced Polymer Modifiers: Acts as a monomer or cross-linking agent for creating specialty polymers with unique thermal, chemical, or surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring novel fluorination chemistry.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses producing tailored compounds for client-specific projects.

Basic Information

Product Name	Methyl A,G-Dioxo-4-Trifluoromethylbenzenebutanoate
CAS No.	608537-00-4
Molecular Formula	C12H9F3O4
Molecular Weight	274.19 g/mol
Synonyms	Methyl 4,4-dioxo-4-[4-(trifluoromethyl)phenyl]butanoate; 4-(4-(Trifluoromethyl)phenyl)-4-oxobutanoic acid methyl ester; Methyl 4-oxo-4-[4-(trifluoromethyl)phenyl]butanoate; Butanoic acid, 4-oxo-4-[4-(trifluoromethyl)phenyl]-, methyl ester; α,γ-Dioxo-4-trifluoromethylbenzenebutanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl A,G-Dioxo-4-Trifluoromethylbenzenebutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.