Description

10-Hydroxynaltrexone is a key pharmaceutical intermediate and metabolite of the opioid antagonist naltrexone. This compound matters for its critical role in advanced pharmaceutical research, development, and quality control processes. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the synthesis of novel therapeutics, metabolic studies, and the production of high-purity reference standards.

Application

• Pharmaceutical Intermediate: Used in the synthesis and development of advanced opioid antagonist drugs and related pharmaceutical compounds.
• Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control testing in pharmaceutical laboratories.
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway research related to naltrexone and its derivatives.
• Active Pharmaceutical Ingredient (API) Manufacturing: A critical building block in the production chain for specialized active pharmaceutical ingredients.
• Biomedical Research: Utilized in preclinical and clinical research investigating opioid receptor mechanisms and addiction treatment.
• Impurity Profiling: Employed to identify and quantify related substances in naltrexone drug products to ensure safety and efficacy.

Basic Information

Product Name	10-Hydroxynaltrexone
CAS No.	604767-82-0
Molecular Formula	C20H23NO5
Molecular Weight	357.40 g/mol
Synonyms	10-Hydroxy naltrexone; 10β-Hydroxynaltrexone; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; Naltrexone Metabolite; Noroxymorphone derivative
EINECS	Contact for details

Quality Control

Our 10-Hydroxynaltrexone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.