Description

3-Formyl-5-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block featuring both a formyl and a carboxylic acid group on a trifluoromethyl-substituted benzene ring. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Building block for advanced polymers and liquid crystals that require specific electronic and steric properties.
• Organic Synthesis: Versatile substrate for various reactions, including condensations, reductions, and cyclizations, to create complex heterocycles and functionalized aromatics.

Basic Information

Product Name	3-Formyl-5-(Trifluoromethyl)Benzoic Acid
CAS No.	604001-03-8
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	5-(Trifluoromethyl)isophthalaldehyde-3-carboxylic acid; 3-Carboxy-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)isophthalic acid 3-aldehyde; 3-Formyl-5-trifluoromethylbenzoic acid; Benzoic acid, 3-formyl-5-(trifluoromethyl)-; 3-Aldehyde-5-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.