Description

Methyl 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical building block in modern organic synthesis, enabling the formation of complex carbon-carbon bonds via cross-coupling reactions. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel fluorinated biaryl compounds with potential therapeutic activity.
• Agrochemical Research: Used in the discovery and development of new generation herbicides and pesticides that incorporate fluorinated aromatic structures.
• Material Science: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where precise molecular architecture is required.
• Chemical Biology: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and imaging agents.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) settings.

Basic Information

Product Name	Methyl 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	603122-52-7
Molecular Formula	C14H18BFO4
Molecular Weight	280.10 g/mol
Synonyms	2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-fluoro-4-(pinacolatoboron)benzoate; 2-Fluoro-4-(pinacolboronato)methyl benzoate; 603122-52-7; Methyl 2-fluoro-4-boronopicolinate pinacol ester (common misnomer); 4-(Pinacolatoboran-2-yl)-2-fluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP guidelines where applicable. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as verified by HPLC, NMR, and other analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.