Description

Co-Amilozide is a high-purity active pharmaceutical ingredient (API) and chemical intermediate, primarily recognized for its role in cardiovascular and diuretic research and formulation. Its significance lies in its dual-action properties, which are critical for developing advanced therapeutic agents. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of combination diuretic and antihypertensive medications.
• Research & Development: Key reference standard and building block in cardiovascular and renal pharmacology studies.
• Fine Chemical Synthesis: Valuable intermediate for the synthesis of more complex, target-specific drug molecules.
• Analytical Standards: Used as a certified reference material (CRM) for quality control and regulatory testing in pharmaceutical analysis.
• Preclinical Studies: Employed in animal models to investigate efficacy, pharmacokinetics, and safety profiles.

Basic Information

Product Name	Co-Amilozide
CAS No.	68529-45-3
Molecular Formula	C24H26ClN7O3S
Molecular Weight	528.03 g/mol
Synonyms	Amiloride Hydrochloride and Hydrochlorothiazide; Amiloride HCl - HCTZ; Hydrochlorothiazide and Amiloride Hydrochloride; Amiloride HCL/HCTZ; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride mixture with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Co-Amiloride HCTZ
EINECS	Contact for details

Quality Control

Our Co-Amilozide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.