Description

Poly(2'-Fluoro-2'-Deoxyadenylic Acid) is a synthetic, fluorinated oligonucleotide analog designed for advanced biochemical and pharmaceutical research. This compound is critical for applications requiring enhanced nuclease resistance and stability, making it a valuable tool for probing biological mechanisms and developing novel therapeutic agents. It is primarily utilized by research institutions and biotechnology companies focused on nucleic acid chemistry, antisense technology, and the development of diagnostic assays.

Application

• Antisense Oligonucleotide Research: Serves as a stable building block for synthesizing antisense strands that modulate gene expression.
• Diagnostic Probe Development: Used in the design of highly specific and stable probes for fluorescence in situ hybridization (FISH) and other detection platforms.
• Biochemical Studies: Employed to study enzyme kinetics, particularly the activity of nucleases and polymerases, due to its modified backbone.
• Pharmaceutical R&D: Acts as a key intermediate in the discovery and development of novel therapeutic oligonucleotides, including aptamers.
• Stability-Enhanced Constructs: Incorporated into oligonucleotide sequences to improve their resistance to degradation in biological matrices.

Basic Information

Product Name	Poly(2'-Fluoro-2'-Deoxyadenylic Acid)
CAS No.	68245-92-1
Molecular Formula	(C10H12FN5O6P)n
Molecular Weight	Contact for details
Synonyms	Poly(2'-F-dAMP); 2'-Fluoro-2'-deoxyadenylic acid homopolymer; Poly(2'-fluoro-2'-deoxyadenosine 5'-monophosphate); 2'-F-2'-dA Polymer; Fluorinated polydeoxyadenylic acid; Oligonucleotide, 2'-fluoro-2'-deoxyadenylic acid; Poly(2'-F-dA)
EINECS	Contact for details

Quality Control

Our Poly(2'-Fluoro-2'-Deoxyadenylic Acid) is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Moisture Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.