Description

(6R-Cis)-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative, essential for the synthesis of modern β-lactam antibiotics. Its high-purity grade is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredients (APIs). This compound is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation cephalosporin antibiotics.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of semi-synthetic cephalosporin antibiotics.
• API Synthesis: Used in the critical chemical steps to produce final Active Pharmaceutical Ingredients (APIs) for injectable and oral antibiotic formulations.
• Research & Development: Serves as a reference standard and starting material in pharmaceutical R&D for novel antibiotic compounds and structure-activity relationship (SAR) studies.
• Process Chemistry: Utilized in scale-up and optimization of manufacturing processes for cephalosporin-class drugs.
• Quality Control: Acts as a high-purity analytical standard for quality testing of related pharmaceutical products.

Basic Information

Product Name	(6R-Cis)-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	68244-05-3
Molecular Formula	C17H16N2O4S
Molecular Weight	344.39 g/mol
Synonyms	7-ADCA-PG; 7-ADCA Phenacetyl Amide; 7-Phenylacetamido-3-methyl-δ3-cephem-4-carboxylic Acid; 7-Phenylacetamido-3-methyl-3-cephem-4-carboxylic Acid; 7-PACA; 7β-Phenylacetamido-3-methyl-3-cephem-4-carboxylic Acid; (6R,7R)-3-Methyl-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (6R-Cis)-3-Methyl-8-Oxo-7-(Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure it meets high-purity pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support our customers' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.