Description

4-Fluoro-3-(trifluoromethyl)benzoic acid is a high-value fluorinated aromatic building block characterized by its benzoic acid core substituted with fluorine and a trifluoromethyl group. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis for complex molecule assembly.
• Chemical Research: Used in academic and industrial R&D labs for exploring new fluorination methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)benzoic Acid
CAS No.	67515-55-3
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzoic acid; 3-Trifluoromethyl-4-fluorobenzoic acid; Benzoic acid, 4-fluoro-3-(trifluoromethyl)-; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluic acid; 4-Fluoro-3-trifluoromethylbenzoic acid; 67515-55-3; 4-Fluoro-α,α,α-trifluoro-m-toluic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)benzoic acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.