Description

Corynanthine Hydrochloride is a high-purity alkaloid derivative, specifically the hydrochloride salt of corynanthine. This compound is a selective α-1 adrenergic receptor antagonist, making it a critical reference standard and research chemical in pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for the development and quality control of cardiovascular and neurological therapeutics. Our supply ensures consistent quality and reliable availability for critical global research and production needs.

Application

• Pharmacological Research: Used as a selective α1-adrenergic receptor antagonist in receptor binding assays and functional studies.
• Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of corynanthine in analytical methods like HPLC and LC-MS.
• Drug Discovery & Development: A key intermediate and tool compound in the research of drugs targeting hypertension, benign prostatic hyperplasia (BPH), and neurological conditions.
• Biochemical Assays: Employed in vitro to study autonomic nervous system pathways and the mechanisms of vasodilation.
• Academic Research: Utilized in university and institutional labs for neuroscience and cardiovascular physiology experiments.
• Pharmaceutical Quality Control: Acts as a system suitability standard and impurity marker in the manufacturing process control of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Corynanthine Hydrochloride
CAS No.	66634-44-4
Molecular Formula	C21H26N2O3·HCl
Molecular Weight	390.90 g/mol
Synonyms	Corynanthine HCl; 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride; Raubasine hydrochloride; α-Yohimbine hydrochloride; 3-Epi-α-yohimbine hydrochloride; (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Corynanthine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.