Description

Quil A is a purified saponin fraction derived from the bark of the *Quillaja saponaria* Molina tree, widely recognized for its potent adjuvant activity in immunological applications. Its primary value lies in its ability to enhance and modulate both humoral and cellular immune responses when formulated with antigens, making it a critical component in modern vaccine development. This product is essential for research institutions, biopharmaceutical companies, and vaccine manufacturers focused on human and veterinary immunotherapeutics, as well as other applications requiring natural surfactant properties.

Application

• Vaccine Adjuvant Formulation: A key immunostimulant in subunit and recombinant vaccine development for both human and veterinary use.
• Immunological Research: Used in laboratory studies to investigate immune response mechanisms and evaluate novel antigen candidates.
• Veterinary Vaccines: Critical component in adjuvants for vaccines protecting livestock, poultry, and companion animals.
• Pharmaceutical Delivery Systems: Explored as a natural surfactant and absorption enhancer in various drug delivery platforms.
• Biochemical Research: Employed as a tool for membrane permeabilization and protein solubilization in cell biology studies.
• Cosmetic & Personal Care: Utilized in high-end formulations for its natural foaming and emulsifying properties.

Basic Information

Product Name	Quil A
CAS No.	66594-14-7
Molecular Formula	Complex mixture of triterpenoid saponins
Molecular Weight	Variable (typically 1650-2000 g/mol for major components)
Synonyms	Quillaja Saponin; Quil-A; Saponin from Quillaja bark; Quillaja Saponaria Molina Extract; QA-21; Immune-stimulating complex (ISCOM) matrix; Triterpenoid saponin fraction; Spikoside
EINECS	Contact for details

Quality Control

Our Quil A is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and performance for critical immunological applications. Each lot is characterized for key parameters including saponin profile, hemolytic activity, and adjuvant potency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95% total saponins
Hemolytic Activity	Defined HU50/mg range
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 2.0 %
Microbial Limits	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.