Description

Acyclovir Triphosphate is a biologically active nucleotide analog triphosphate essential for antiviral research and development. This compound serves as a critical substrate for DNA polymerases, enabling the study of viral replication mechanisms and the inhibition of herpesviruses. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic research institutions focused on virology and nucleoside chemistry.

Application

• Antiviral Research & Development: Used as a key biochemical tool to study the mechanism of action and efficacy of nucleoside analogs against herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV).
• Enzyme Kinetics Studies: Serves as a specific substrate for viral DNA polymerases (like HSV DNA polymerase) to measure enzyme activity, inhibition constants (Ki), and catalytic efficiency.
• Diagnostic Assay Development: Employed in the development of high-throughput screening (HTS) assays and diagnostic kits to identify and characterize new antiviral compounds.
• Biochemical Synthesis: Acts as a building block for the enzymatic synthesis of labeled DNA probes or for studying DNA chain termination events in controlled in vitro systems.
• Academic & Pharmaceutical Research: A fundamental reagent for investigating viral resistance mechanisms, drug metabolism pathways, and the structural biology of polymerase-substrate interactions.

Basic Information

Product Name	Acyclovir Triphosphate
CAS No.	66341-18-2
Molecular Formula	C8H15N5O12P3
Molecular Weight	506.15 g/mol
Synonyms	ACV-TP; Acyclovir 5'-Triphosphate; 9-[(2-Hydroxyethoxy)methyl]guanine 5'-triphosphate; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one 5'-(trihydrogen triphosphate); Acycloguanosine triphosphate; BW 248U Triphosphate; Zovirax Triphosphate (analog)
EINECS	Contact for details

Quality Control

Our Acyclovir Triphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.