Description

(2S,5R,6S)-6-[(3-Hydroxy-3-Oxo-2-Thiophen-3-Ylpropanoyl)Amino]-6-Methoxy-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex β-lactam core structure. This compound is critical for the synthesis of novel cephalosporin antibiotics, offering a key building block for research and development in antimicrobial therapies. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing next-generation antibacterial agents to address evolving resistance patterns.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of advanced cephalosporin-class antibiotics.
• Antibacterial Drug Development: Used in R&D for creating new antibacterial compounds with potentially improved efficacy and spectrum of activity.
• Chemical Synthesis Research: Employed in academic and industrial laboratories for studying structure-activity relationships (SAR) in β-lactam chemistry.
• Process Chemistry: Integral to scaling up and optimizing manufacturing routes for target active pharmaceutical ingredients (APIs).
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	(2S,5R,6S)-6-[(3-Hydroxy-3-Oxo-2-Thiophen-3-Ylpropanoyl)Amino]-6-Methoxy-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid
CAS No.	66148-78-5
Molecular Formula	C17H20N2O7S2
Molecular Weight	428.48 g/mol
Synonyms	6-[(3-Hydroxy-3-oxo-2-(thiophen-3-yl)propanoyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6S)-6-Methoxy-3,3-dimethyl-7-oxo-6-[(2-(3-thienyl)-3-hydroxy-3-oxopropanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; A key intermediate for Cefditoren; Cefditoren Pivoxil intermediate; β-Lactam antibiotic intermediate; 4-Thia-1-azabicyclo[3.2.0]heptane derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.