Description

n-Piperacillinyl Ampicillin is a key semi-synthetic intermediate in the synthesis of advanced β-lactam antibiotics. This compound matters for its critical role in producing potent, broad-spectrum antimicrobial agents, enabling pharmaceutical manufacturers to address complex bacterial infections. It is primarily needed by pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) producers focused on developing next-generation penicillin derivatives and combination therapies.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced β-lactam antibiotic APIs.
• Antibiotic Research & Development: Serves as a crucial building block for creating novel penicillin and piperacillin-based drug candidates.
• Combinatorial Chemistry: Used in libraries for screening new antimicrobial compounds with enhanced efficacy.
• Process Chemistry & Scale-up: Employed in optimizing manufacturing routes for bulk antibiotic production.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-Piperacillinyl Ampicillin
CAS No.	65772-67-0
Molecular Formula	C23H30N6O7S2
Molecular Weight	566.66 g/mol
Synonyms	6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Ampicillin Piperacillinyl Ester; Piperacillin Ampicillin Derivative; (2S,5R,6R)-6-[(2R)-2-[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; BL-P 1908; T-1220 Intermediate
EINECS	Contact for details

Quality Control

Our n-Piperacillinyl Ampicillin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.