Description

Poly(2'-Chloro-2'-Deoxyadenylic Acid) is a chemically modified nucleotide polymer, specifically a chlorinated derivative of deoxyadenylic acid. This modification imparts unique properties, making it a critical intermediate and research tool in advanced nucleic acid chemistry and oligonucleotide synthesis. It is primarily utilized by research institutions and pharmaceutical developers working on novel therapeutic modalities, diagnostic probes, and molecular biology applications. The compound is supplied to meet the stringent purity requirements of these high-value, innovation-driven fields.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite or solid-phase synthesis building block for creating modified DNA/RNA strands.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides where backbone modification enhances stability and target binding.
• Molecular Probes: Incorporated into diagnostic probes and primers to alter hybridization kinetics or provide sites for further conjugation.
• Biochemical Research: Employed in enzymatic studies to investigate polymerase activity, DNA repair mechanisms, and substrate specificity.
• Pharmaceutical Intermediate: Acts as a crucial precursor in the research and development stages of nucleotide-based drugs.
• Academic Research: Utilized in universities and institutes for fundamental studies in chemical biology and nucleic acid structure-function relationships.

Basic Information

Product Name	Poly(2'-Chloro-2'-Deoxyadenylic Acid)
CAS No.	65456-04-4
Molecular Formula	(C10H12ClN5O5P)n
Molecular Weight	Monomer: 339.66 g/mol (Contact for polymer chain length details)
Synonyms	Poly(2'-Cl-2'-dA); 2'-Chloro-2'-deoxyadenylic Acid Homopolymer; Poly(2'-chloro-2'-deoxyadenosine 5'-phosphate); Chlorinated Polydeoxyadenylic Acid; Poly(Cl-dAMP); Poly(2'-Cl-dAMP); Research Oligonucleotide Intermediate; Modified DNA Polymer
EINECS	Contact for details

Quality Control

Every batch of Poly(2'-Chloro-2'-Deoxyadenylic Acid) is produced and analyzed under controlled conditions to ensure consistent quality suitable for research and development. Our quality assurance protocol includes rigorous testing for identity, purity, and composition. A comprehensive Certificate of Analysis (COA) detailing specific batch results from HPLC, NMR, and other relevant analytical methods is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or desiccant after each use to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR/IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Polymer)
Chloro Content	As per theoretical
Solubility	Soluble in alkaline aqueous buffers, DMSO
Moisture Content (KF)	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.