Description

Aldactazide is a well-known pharmaceutical compound, a combination of spironolactone and hydrochlorothiazide, primarily used as a diuretic and antihypertensive agent. This product is essential for the development and manufacturing of critical medications that manage conditions like hypertension, edema, and heart failure. It is a key active pharmaceutical ingredient (API) and intermediate for pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical API: Primary use as the active ingredient in combination diuretic and antihypertensive medications.
• Hypertension Treatment: Formulated into tablets and capsules for the management of high blood pressure.
• Edema Management: Used in medications to reduce fluid retention associated with congestive heart failure, liver cirrhosis, and nephrotic syndrome.
• Clinical Research: Serves as a reference standard and key material in pharmacological studies and clinical trials.
• Generic Drug Manufacturing: A critical component for producers of generic pharmaceutical formulations.
• Fine Chemical Synthesis: Used as a high-purity intermediate in advanced organic synthesis for related compound development.

Basic Information

Product Name	Aldactazide
CAS No.	65272-36-8
Molecular Formula	C24H32ClN2O5S2 + C7H8ClN3O4S2
Molecular Weight	Spironolactone: 416.57 g/mol; Hydrochlorothiazide: 297.74 g/mol
Synonyms	Spironolactone and Hydrochlorothiazide; Spironolactone/HCTZ; Aldactone-H; Spiro-HCTZ; Spironolactone Hydrochlorothiazide Combination; Spironolactone Compound; Spironolactone-Hydrochlorothiazide Mixture; 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone and 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
EINECS	Contact for details

Quality Control

Our Aldactazide is produced under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes rigorous analytical testing including identity, purity, and impurity profile analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, related substances, residual solvents, and microbiological quality to ensure it meets the stringent requirements of pharmaceutical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.