Description

Talisomycin CAS NO 65057-90-1 is a potent ansamycin antibiotic belonging to the geldanamycin family, known for its activity as an Hsp90 inhibitor. This compound is of significant interest in biochemical and pharmacological research for its ability to modulate heat shock protein function, impacting protein folding and client protein stability. It serves as a critical tool for researchers in oncology, neurodegenerative disease studies, and molecular biology, where precise disruption of Hsp90-mediated pathways is required.

Application

• Biochemical Research: Used as a specific inhibitor of Hsp90 (Heat Shock Protein 90) to study protein folding, chaperone function, and cellular stress response pathways.
• Oncology Research: Investigated for its potential to induce degradation of oncogenic client proteins, making it a valuable compound for studying cancer cell proliferation and apoptosis.
• Neurodegenerative Disease Models: Employed in research models for diseases like Alzheimer's and Parkinson's to understand the role of protein aggregation and chaperone systems.
• Antimicrobial Studies: Studied for its inherent antibiotic properties against certain bacterial strains, contributing to microbiology and infectious disease research.
• Signal Transduction Analysis: A key reagent for dissecting kinase signaling pathways that are dependent on Hsp90 for stability and function.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery and development of novel Hsp90-targeted therapeutics.

Basic Information

Product Name	Talisomycin
CAS No.	65057-90-1
Molecular Formula	C34H46N2O10
Molecular Weight	642.74 g/mol
Synonyms	Talisomycin A; Antibiotic U-59,965; NSC-330500; 15-Deoxy-15-demethylgeldanamycin; Ansamycin antibiotic U-59965; Benzoquinoid ansamycin; Hsp90 inhibitor Talisomycin
EINECS	Contact for details

Quality Control

Our Talisomycin is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We ensure compliance with relevant standards for research-grade biochemicals, and specifications can be provided to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic and light-sensitive nature, the product should be handled under inert conditions when possible and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.