Description

S(-)-Baclofen Hcl CAS NO 63701-56-4 is the single enantiomer of the muscle relaxant Baclofen, specifically the S(-) stereoisomer. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in studying stereospecific receptor interactions and developing targeted neurological therapies. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for its precise pharmacological activity.

Application

• Pharmaceutical Research & Development: As a key reference standard and building block for investigating GABAB receptor pharmacology and developing novel central nervous system (CNS) agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production of enantiomerically pure Baclofen-based medications for conditions like muscle spasticity.
• Neurological Studies: Employed in preclinical and clinical research to understand the stereospecific effects of Baclofen on spinal cord reflexes and neurotransmission.
• Analytical Standard: Serves as a high-purity standard for method development and quality control (HPLC, GC, chiral analysis) in pharmaceutical testing laboratories.
• Academic & Clinical Research: Utilized in university and hospital labs for studies on spasticity management, addiction treatment, and other neurological disorders.

Basic Information

Product Name	S(-)-Baclofen Hcl
CAS No.	63701-56-4
Molecular Formula	C10H12ClNO2 • HCl
Molecular Weight	250.12 g/mol (as hydrochloride salt)
Synonyms	(S)-(-)-Baclofen Hydrochloride; (-)-Baclofen Hydrochloride; (3S)-4-Amino-3-(4-chlorophenyl)butanoic acid hydrochloride; L-Baclofen HCl; (S)-Baclofen HCl; Baclofen Impurity C (S-enantiomer); β-(Aminomethyl)-4-chloro-benzenepropanoic acid hydrochloride (S-form); GABOB derivative
EINECS	Contact for details

Quality Control

Our S(-)-Baclofen Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high enantiomeric purity and chemical identity, meeting the stringent requirements for pharmaceutical research materials. A Certificate of Analysis (COA) detailing specifications such as assay, enantiomeric excess (e.e.), and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% e.e.
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.