Description

Capreomycin Iib is a second-generation cyclic peptide antibiotic belonging to the capreomycin family, identified by CAS NO 62639-90-1. It is a critical component in the treatment of multidrug-resistant tuberculosis (MDR-TB), offering a vital therapeutic option where first-line treatments fail. This high-purity pharmaceutical intermediate is essential for research institutions, diagnostic kit manufacturers, and pharmaceutical companies developing and producing advanced anti-tuberculosis medications.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key component in the formulation of second-line injectable anti-tuberculosis drugs for treating MDR-TB.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of TB drug products.
• Biomedical Research: Employed in microbiological and pharmacological studies to investigate mechanisms of action, resistance, and synergistic effects against *Mycobacterium tuberculosis*.
• Diagnostic Development: Utilized in the research and production of diagnostic assays and kits for detecting TB strains and their susceptibility profiles.
• Process Chemistry: Acts as an intermediate in the synthetic or semi-synthetic production pathways of complex anti-tuberculosis agents.

Basic Information

Product Name	Capreomycin Iib
CAS No.	62639-90-1
Molecular Formula	C25H44N14O8
Molecular Weight	668.71 g/mol
Synonyms	Capreomycin IB; Capreomycin IIB; Capreomycin 1B; Capreomycin 2B; Capastat component IIB; (S)-4,6-Diamino-N-((1R,2S,3S,4R,6S)-4,6-diamino-2-((S)-3-((S)-3-((S)-2-amino-3-guanidinopropanamido)-3-hydroxypropanamido)-2-hydroxypropanamido)-3-hydroxycyclohexyl)-2-hydroxyhexanamide; Cyclic peptide antibiotic from *Streptomyces capreolus*.
EINECS	Contact for details

Quality Control

Our Capreomycin Iib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent limits for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with relevant pharmacopeial guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.