Description

3-Amino-4-Imino-Rifamycin S is a key semi-synthetic derivative of the rifamycin antibiotic class, serving as a crucial intermediate in pharmaceutical synthesis. Its primary value lies in its role as a precursor for developing advanced rifamycin-based antibiotics, which are essential in treating serious bacterial infections, including tuberculosis. This high-purity intermediate is critically needed by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antimicrobial therapies.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of potent rifamycin antibiotics like rifampin and rifabutin.
• Antimicrobial Research: Used in R&D for developing novel antibiotics targeting drug-resistant bacterial strains (MDR-TB).
• Biochemical Studies: Employed in studies investigating the mechanism of action of RNA polymerase inhibition.
• Reference Standard: Serves as a high-purity analytical standard for quality control in antibiotic manufacturing.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for commercial antibiotic production.

Basic Information

Product Name	3-Amino-4-Imino-Rifamycin S
CAS No.	62041-01-4
Molecular Formula	C37H47N3O12
Molecular Weight	725.79 g/mol
Synonyms	3-Amino-4-imino-1,4-didehydro-1-deoxy-1,4-dihydro-5'-hydroxy-rifamycin SV; 3-Amino-4-iminorifamycin S; 4-Imino-3-aminorifamycin S; Rifamycin S, 3-amino-4-imino-; 3-Amino-4-imino-1,4-didehydro-1-deoxy-1,4-dihydro-5'-hydroxy-rifamycin SV; 3-Amino-4-imino-1,4-didehydro-1-deoxy-1,4-dihydro-5'-hydroxy-rifamycin SV (non-preferred name)
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Imino-Rifamycin S is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Production adheres to current industry best practices, and each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for active pharmaceutical ingredient (API) intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Reddish-brown to dark red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.