Description

Temocillin is a semi-synthetic, β-lactamase-stable penicillin antibiotic derived from ticarcillin. Its primary value lies in its potent and specific activity against Gram-negative bacteria, including many multi-resistant strains, due to its stability against a broad spectrum of β-lactamase enzymes. This makes it a critical agent for research and development in antimicrobial resistance studies and for the formulation of specialized pharmaceutical intermediates. Key industries requiring this compound include pharmaceutical R&D, reference standard production, and advanced chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified standard in analytical laboratories for quality control and method validation of antibiotic products.
• Antimicrobial Research: Serves as a key active ingredient in microbiological research focused on Gram-negative infections and β-lactamase inhibition studies.
• Intermediate Synthesis: Employed as a high-purity building block in the synthesis of novel antibiotic derivatives and prodrug development.
• In-vitro Diagnostics: Incorporated into culture media and susceptibility testing kits for clinical and research microbiology.
• Veterinary Medicine R&D: Investigated for potential applications in treating bacterial infections in animals.

Basic Information

Product Name	Temocillin
CAS No.	61545-06-0
Molecular Formula	C16H20N4O7S2
Molecular Weight	468.48 g/mol
Synonyms	Temocillin; BRL 17421; 6β-[[(Carboxy-3-thienylacetyl)amino]penicillanic acid 1,1-dioxide; (2S,5R,6R)-6-[[(2R)-2-Carboxy-2-(thiophen-3-yl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; Temopen; Negaban
EINECS	Contact for details

Quality Control

Our Temocillin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with relevant research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.