Description

Piperacillin CAS NO 61477-96-1 is a broad-spectrum, semi-synthetic β-lactam antibiotic belonging to the ureidopenicillin class. It is a critical active pharmaceutical ingredient (API) valued for its potent activity against a wide range of Gram-negative and Gram-positive bacteria, including *Pseudomonas aeruginosa*. This compound is essential for pharmaceutical manufacturers producing injectable antibiotic formulations, particularly in combination with β-lactamase inhibitors like tazobactam. Its primary application is in the synthesis of finished dosage forms for hospital and clinical use in treating serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Combination Therapy: Used in the manufacture of combination drugs, most notably piperacillin/tazobactam, for enhanced efficacy against β-lactamase-producing bacteria.
• Hospital Infection Treatment: Essential for producing medications to treat nosocomial infections such as intra-abdominal infections, pneumonia, and septicemia.
• Bulk Drug Substance: Sourced by generic and innovator pharmaceutical companies for finished product manufacturing under GMP guidelines.
• Research & Development: Used in microbiological research, antimicrobial susceptibility testing, and development of new therapeutic combinations.

Basic Information

Product Name	Piperacillin
CAS No.	61477-96-1
Molecular Formula	C23H27N5O7S
Molecular Weight	517.56 g/mol
Synonyms	Piperacillin; Piperacillinum; Piperacilina; (2S,5R,6R)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Pipril; Pentcillin; Pipracil; T-1220; PC-904; Avocin; Pipril
EINECS	262-818-8

Quality Control

Our Piperacillin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Quality specifications are aligned with major pharmacopoeial standards, including USP and EP, ensuring reliability for GMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Microbial Enumeration	Meets USP/EP criteria for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.