Description

Rolipram is a potent and selective phosphodiesterase 4 (PDE4) inhibitor widely recognized for its significant role in biochemical and pharmacological research. This compound is a critical tool for investigating intracellular signaling pathways, particularly those related to inflammation and neurological function. It is essential for researchers and developers in the pharmaceutical and life sciences sectors, serving as a key reference standard and active compound in the study of depression, memory disorders, and inflammatory diseases.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel antidepressant and anti-inflammatory drugs.
• Biochemical Assays: Used as a selective PDE4 inhibitor to study cyclic adenosine monophosphate (cAMP) signaling pathways in cell-based and enzymatic assays.
• Neuropharmacology Studies: A vital tool for investigating mechanisms related to memory, learning, and neurodegenerative conditions.
• Inflammation Research: Employed in models to understand and modulate inflammatory responses, particularly in diseases like asthma and COPD.
• Academic Research: Utilized in university and institutional labs for fundamental research on cell signaling and drug discovery.
• Chemical Synthesis: Serves as a key intermediate or building block for the synthesis of more complex PDE4-targeting molecules.

Basic Information

Product Name	Rolipram
CAS No.	61413-54-5
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (R,S)-Rolipram; ZK 62711; Ro 20-1724; PDE4 Inhibitor IV; 3-Cyclopentyloxy-4-methoxy-N-2-pyrrolidinonebenzamide
EINECS	Contact for details

Quality Control

Our Rolipram is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We support research and development with material that meets the stringent requirements for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.