Description

2-Dimethylaminonaphthalene-6-Sulfonyl Chloride is a specialized sulfonyl chloride derivative of the dansyl fluorophore, serving as a critical building block for the synthesis of fluorescent probes and labels. Its core value lies in its ability to react with amines, alcohols, and thiols to form stable, highly fluorescent conjugates, enabling sensitive detection and analysis. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and analytical chemistry who require high-purity reagents for tagging biomolecules.

Application

• Fluorescent Labeling Reagent: Primary use for tagging proteins, peptides, and amino acids to create dansyl derivatives for fluorescence spectroscopy and HPLC analysis.
• Proteomics Research: Used in the preparation of fluorescent markers for studying protein structure, function, and interactions.
• Pharmaceutical Analysis: Acts as a derivatization agent for the sensitive detection and quantification of amine-containing drugs and their metabolites.
• Bioconjugation Chemistry: A key intermediate for synthesizing fluorescent dyes and probes used in bioimaging and diagnostic assays.
• Material Science: Potential use in the development of advanced polymeric materials with fluorescent properties.

Basic Information

Product Name	2-Dimethylaminonaphthalene-6-Sulfonyl Chloride
CAS No.	60151-27-1
Molecular Formula	C₁₂H₁₂ClNO₂S
Molecular Weight	269.75 g/mol
Synonyms	Dansyl chloride; 5-(Dimethylamino)naphthalene-1-sulfonyl chloride; DNSC; DANSYL-Cl; 1-Dimethylaminonaphthalene-5-sulfonyl chloride; DNS-Cl; 5-Dimethylamino-1-naphthalenesulfonyl chloride
EINECS	262-100-8

Quality Control

Our 2-Dimethylaminonaphthalene-6-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical methods to guarantee product integrity and performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	69 - 73 °C
Loss on Drying	≤ 1.0 %
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.