Description

Ethacrynate is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial and research importance. Its primary value lies in its role as the key metabolite and active form of the potent loop diuretic ethacrynic acid, which is used to manage edema associated with congestive heart failure and hepatic or renal disease. This compound is essential for pharmaceutical manufacturers, analytical reference standard producers, and research institutions focused on cardiovascular pharmacology, diuretic development, and metabolic studies.

Application

• Pharmaceutical API Synthesis: Primary use as a critical intermediate in the manufacture of ethacrynic acid and related diuretic medications.
• Analytical Reference Standard: Serves as a certified standard for quality control (QC) and assay development in pharmaceutical laboratories.
• Biomedical Research: Utilized in pharmacological studies to investigate the mechanisms of loop diuretics, renal physiology, and sodium-potassium-chloride cotransporter inhibition.
• Metabolite Studies: Key for in vitro and in vivo studies examining the metabolism, pharmacokinetics, and pharmacodynamics of ethacrynic acid.
• Chemical Biology Probes: Used in developing probes to study protein interactions, particularly with enzymes containing reactive cysteine residues, due to its α,β-unsaturated ketone moiety.

Basic Information

Product Name	Ethacrynate
CAS No.	6500-81-8
Molecular Formula	C13H12Cl2O4
Molecular Weight	303.14 g/mol
Synonyms	Ethacrynic Acid Metabolite; [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic Acid; Ethacrynate Sodium (salt form); Etacrynate; MK-595 Metabolite; NSC 85791; Ethacrynic Acid Derivative; 2,3-Dichloro-4-(2-methyl-1-oxobut-1-en-3-yl)phenoxyacetic Acid
EINECS	Contact for details

Quality Control

Our Ethacrynate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters. Production can be aligned with cGMP guidelines for pharmaceutical applications, and we support compliance with global regulatory standards including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.