Description

n-Methyl-Bis(Trifluoroacetamide) is a versatile fluorinated reagent and derivatization agent prized for its high reactivity and volatility. This compound is essential for introducing the trifluoroacetamide protecting group and for acting as a precursor in the synthesis of complex fluorinated molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring precise fluorination or analytical derivatization.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Analytical Derivatization Agent: Employed in Gas Chromatography (GC) and Mass Spectrometry (MS) to improve the volatility and detection of polar compounds like amines and alcohols.
• Fluorinated Polymer & Material Science: Serves as a building block for creating specialty polymers, coatings, and liquid crystals with unique thermal, chemical, and surface properties.
• Protecting Group Chemistry: Acts as a protecting agent for amines during multi-step synthetic sequences, offering stability under a range of reaction conditions.
• Organic Synthesis Reagent: A valuable tool in academic and industrial R&D for constructing complex molecular architectures via nucleophilic substitution or condensation reactions.

Basic Information

Product Name	n-Methyl-Bis(Trifluoroacetamide)
CAS No.	685-27-8
Molecular Formula	C5H5F6NO2
Molecular Weight	225.09 g/mol
Synonyms	N-Methylbis(trifluoroacetamide); Bis(trifluoroacetamide), N-methyl-; MBTFA; Methylbis(trifluoroacetamide); N-Methyl-N,N-bis(trifluoroacetyl)amine; N-Methylbis(trifluoroacetamide) derivatizing reagent; 1,1,1,1',1',1'-Hexafluoro-N-methyldiacetamide
EINECS	211-689-7

Quality Control

Our n-Methyl-Bis(Trifluoroacetamide) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, ensure containers are securely sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.5 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.