Description

2-Chloro-5-(Trifluoromethyl)Benzoic Acid is a versatile and high-value fluorinated aromatic building block. This compound is prized for its unique combination of a carboxylic acid group and electron-withdrawing chloro- and trifluoromethyl substituents, which impart significant reactivity and influence on molecular properties. It is primarily sought after by R&D chemists and process developers in the pharmaceutical and agrochemical industries for synthesizing advanced intermediates and active ingredients. Its structural features make it a critical component in the development of novel compounds with enhanced biological activity and physical characteristics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification Agent: Employed to introduce functional aromatic groups into polymer chains, modifying thermal stability, chemical resistance, and other material properties.
• Organic Synthesis & Catalysis Research: A valuable reagent in academic and industrial research for studying new coupling reactions, catalytic cycles, and the synthesis of complex organic molecules.
• Dye & Pigment Intermediate: Utilized in the manufacture of specialized dyes and pigments where the halogen and fluorine atoms alter color fastness and spectral properties.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	657-06-7
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-toluic acid; 2-Chloro-α,α,α-trifluoro-4-methylbenzoic acid; Benzoic acid, 2-chloro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-chlorobenzoic acid; 2-Chloro-5-trifluoromethylbenzoic acid; 2-Chloro-α,α,α-trifluoro-p-toluic Acid; 2-Chloro-5-(trifluoromethyl)benzoic acid
EINECS	211-491-4

Quality Control

Our production of 2-Chloro-5-(Trifluoromethyl)Benzoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity. All materials undergo comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our facility operates under a quality system designed to meet the rigorous standards required by our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	155 - 160 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.