Description

2-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the benzoyl chloride functionality with chloro and trifluoromethyl substituents, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to introduce key structural motifs into active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the 2-chloro-5-(trifluoromethyl)benzoyl moiety.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials and functional dyes.
• Polymer Chemistry: Acts as a monomer or modifying agent for producing specialty polymers with specific thermal or chemical resistance properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce acyl groups into complex molecules under controlled conditions.
• Chemical Research & Development: A valuable tool for medicinal chemistry and material science research to explore new compound libraries and structure-activity relationships.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	657-05-6
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-toluoyl Chloride; 2-Chloro-α,α,α-trifluoro-p-toluic Acid Chloride; 2-Chloro-5-(trifluoromethyl)benzoic acid chloride; 5-(Trifluoromethyl)-2-chlorobenzoyl chloride; Benzoyl chloride, 2-chloro-5-(trifluoromethyl)-; p-(Trifluoromethyl)-o-chlorobenzoyl chloride
EINECS	211-500-8

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and product integrity for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.