Description

2,2-Difluorobenzodioxole-5-Carboxylic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in its unique difluorobenzodioxole scaffold, which imparts desirable properties such as metabolic stability and lipophilicity to target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve compound stability and efficacy.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated polymers or ligands with unique electronic or surface properties.
• Organic Electronics Research: Investigated as a building block for charge-transport materials or emissive layers in OLEDs due to its aromatic, fluorinated structure.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for bespoke synthesis projects requiring this specific fluorinated carboxylic acid.

Basic Information

Product Name	2,2-Difluorobenzodioxole-5-Carboxylic Acid
CAS No.	656-46-2
Molecular Formula	C8H4F2O4
Molecular Weight	202.11 g/mol
Synonyms	5-Carboxy-2,2-difluorobenzodioxole; 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid; 1,3-Benzodioxole-5-carboxylic acid, 2,2-difluoro-; Difluorobenzodioxole carboxylic acid; 656-46-2; Benzodioxole-5-carboxylic acid, 2,2-difluoro-
EINECS	Contact for details

Quality Control

Our 2,2-Difluorobenzodioxole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.