Description

5-Chloro-2-(Trifluoromethyl)Benzoicacid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and carboxylic acid functional groups, which are critical for modulating the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for coupling reactions (e.g., amide bond formation) and for introducing the 5-chloro-2-(trifluoromethyl)phenyl moiety into complex molecules.
• Material Science Research: Employed in the development of novel organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Benzoicacid
CAS No.	654-98-8
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	5-Chloro-α,α,α-trifluoro-o-toluic acid; 2-Trifluoromethyl-5-chlorobenzoic acid; 5-Chloro-2-(trifluoromethyl)benzoic acid; Benzoic acid, 5-chloro-2-(trifluoromethyl)-; 5-Chloro-α,α,α-trifluoro-2-methylbenzoic acid; 654-98-8; 5-Chloro-2-trifluoromethylbenzoic acid
EINECS	211-492-8

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Benzoicacid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.