Description

Clopamide is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the sulfonamide diuretic class. Its primary commercial value lies in its critical role as a key building block for the synthesis of antihypertensive and diuretic medications. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring reliable, high-quality raw materials for drug development and production.

Application

• Pharmaceutical API Synthesis: Primary use as an active ingredient in the manufacture of diuretic and antihypertensive drugs.
• Research & Development: Serves as a key reference standard and intermediate in pharmacological and medicinal chemistry research.
• Fine Chemical Production: Used as a specialized intermediate for synthesizing more complex sulfonamide-derived compounds.
• Formulation Development: Employed in the development of solid dosage forms like tablets and capsules in pre-clinical and clinical trials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant drug production.

Basic Information

Product Name	Clopamide
CAS No.	636-54-4
Molecular Formula	C14H20ClN3O3S
Molecular Weight	345.84 g/mol
Synonyms	4-Chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoylbenzamide; 4-Chloro-3-sulfamoyl-N-(2,6-dimethylpiperidino)benzamide; Chlorthalidone related compound; SR 720-22; Adurix; Brinaldix; Aquex
EINECS	211-280-6

Quality Control

Our Clopamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is tested against rigorous in-house specifications, which typically include identity confirmation, assay, and control of related substances and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results and confirming compliance. We support customers requiring material for GMP (Good Manufacturing Practice) applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.