Description

Dansyl Chloride is a highly reactive fluorescent labeling reagent widely used for the derivatization of amino acids, peptides, and proteins. Its core value lies in its ability to form stable, intensely fluorescent sulfonamide derivatives, enabling sensitive detection and analysis in complex matrices. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors who require precise detection of primary and secondary amines.

Application

• Fluorescent Labeling of Amines: Primary reagent for pre-column or post-column derivatization in High-Performance Liquid Chromatography (HPLC) for amino acid analysis.
• Protein & Peptide Sequencing: Used in Edman degradation and other sequencing methods to label and identify N-terminal amino acids.
• Biomarker Detection: Employed in clinical and forensic toxicology to detect and quantify biogenic amines, neurotransmitters, and pharmaceutical metabolites.
• Proteomics Research: A tool for labeling proteins to study protein structure, function, interactions, and post-translational modifications.
• Quality Control (QC) Testing: Critical for purity assessment and impurity profiling of peptide-based active pharmaceutical ingredients (APIs).
• Food & Beverage Analysis: Applied in the detection of amino acids and biogenic amines (e.g., histamine) for safety and quality testing.

Basic Information

Product Name	Dansyl Chloride
CAS No.	605-65-2
Molecular Formula	C12H12ClNO2S
Molecular Weight	269.75 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl chloride; DNS-Cl; 1-Dimethylaminonaphthalene-5-sulfonyl chloride; Dan syl chloride; DANSYL-Cl; Dns-Cl
EINECS	210-092-3

Quality Control

Our Dansyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive analytical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the container to reach ambient temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	69 - 72 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.