Description

2-(Trifluoromethyl)Quinoline-8-Carboxylic Acid is a high-value, multifunctional heterocyclic building block characterized by its quinoline core and trifluoromethyl substituent. This compound is essential for advanced research and development, particularly in the synthesis of complex molecules where the introduction of fluorine atoms and a carboxylic acid handle is required. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and other organic transformations.
• Material Science Research: Employed in the synthesis of organic semiconductors, fluorescent dyes, and other advanced functional materials due to its electron-deficient quinoline structure.
• Chemical Biology Probes: Utilized as a building block for designing molecular probes and tags to study biological processes and protein interactions.

Basic Information

Product Name	2-(Trifluoromethyl)Quinoline-8-Carboxylic Acid
CAS No.	588702-63-0
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	8-Quinolinecarboxylic acid, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-8-quinolinecarboxylic acid; Quinoline-8-carboxylic acid, 2-(trifluoromethyl)-; 2-Trifluoromethylquinoline-8-carboxylic acid; 2-CF3-Quinoline-8-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Quinoline-8-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.