Description

3-Fluoro-5-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated aromatic building block characterized by its cinnamic acid backbone and strategically positioned fluorine and trifluoromethyl groups. This compound matters for its role in modulating the physicochemical properties of target molecules, including lipophilicity, metabolic stability, and binding affinity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine motifs enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Chemical Biology Probes: Employed as a building block for fluorescent tags and molecular probes used in bioimaging and diagnostic assays.
• Polymer Modification: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, or optical characteristics.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions like Suzuki-Miyaura or Heck couplings for constructing complex biaryl systems.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Cinnamic Acid
CAS No.	575469-96-4
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[3-Fluoro-5-(trifluoromethyl)phenyl]acrylic acid; 3-Fluoro-5-(trifluoromethyl)cinnamic acid; (2E)-3-[3-Fluoro-5-(trifluoromethyl)phenyl]prop-2-enoic acid; trans-3-Fluoro-5-trifluoromethylcinnamic acid; 3-Fluoro-α,α,α-trifluoro-m-cinnamic Acid; 575469-96-4; 3-Fluoro-5-(trifluoromethyl)benzeneacrylic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.