Description

trans-4-Bromo-2-Fluorocinnamic acid is a high-purity, halogenated cinnamic acid derivative characterized by its specific stereochemistry and functional group arrangement. This compound serves as a versatile and critical pharmaceutical intermediate and organic building block for advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used as a building block for developing new herbicides and fungicides with enhanced activity and selectivity.
• Liquid Crystal & OLED Material Synthesis: Serves as a core component for creating advanced organic electronic materials due to its halogenated aromatic structure.
• Cross-Coupling Reactions: An essential substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein interactions.
• Polymer Modification: Acts as a monomer or modifier to introduce specific functional groups into polymer chains, altering material properties.

Basic Information

Product Name	trans-4-Bromo-2-Fluorocinnamic acid
CAS No.	575469-65-7
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	(E)-3-(4-Bromo-2-fluorophenyl)acrylic acid; 4-Bromo-2-fluorocinnamic acid, trans-; (2E)-3-(4-Bromo-2-fluorophenyl)-2-propenoic acid; trans-3-(4-Bromo-2-fluorophenyl)acrylic acid; (E)-3-(4-Bromo-2-fluorophenyl)-2-propenoic acid; 2-Fluoro-4-bromocinnamic acid; (E)-4-Bromo-2-fluorocinnamic acid
EINECS	Contact for details

Quality Control

Our trans-4-Bromo-2-Fluorocinnamic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.