Description

2-[(tert-Butoxycarbonyl)Amino]-3-(Trifluoromethoxy)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its protected amino and trifluoromethoxy functional groups. This compound is critical for the synthesis of complex molecules, offering precise structural control and enhanced metabolic stability in target compounds. It is primarily required by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry programs focused on protease inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for targeted therapies.
• Protease Inhibitor Development: Used in research and production of inhibitors for various viral and disease-related proteases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Synthesis: Employed in creating advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Peptidomimetic Chemistry: Integral for constructing non-peptide compounds that mimic peptide structures for enhanced drug-like properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial drugs.

Basic Information

Product Name	2-[(tert-Butoxycarbonyl)Amino]-3-(Trifluoromethoxy)Benzoic Acid
CAS No.	561304-40-3
Molecular Formula	C₁₃H₁₄F₃NO₅
Molecular Weight	321.25 g/mol
Synonyms	Boc-3-(Trifluoromethoxy)anthranilic Acid; 2-[(tert-Butoxycarbonyl)amino]-3-(trifluoromethoxy)benzoic acid; 3-(Trifluoromethoxy)-2-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid; 2-(Boc-amino)-3-(trifluoromethoxy)benzoic acid; N-Boc-2-amino-3-(trifluoromethoxy)benzoic acid; 2-Amino-3-(trifluoromethoxy)benzoic acid tert-butyl carbamate; Boc-ATFBA
EINECS	Contact for details

Quality Control

Our production of 2-[(tert-Butoxycarbonyl)Amino]-3-(Trifluoromethoxy)Benzoic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.