Description

Telavancin Hydrochloride is a semi-synthetic lipoglycopeptide antibiotic derived from vancomycin. It is a critical pharmaceutical active ingredient valued for its potent bactericidal activity against Gram-positive pathogens, including multidrug-resistant strains. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced treatments for serious skin and skin structure infections, as well as hospital-acquired pneumonia. Telavancin Hydrochloride CAS NO 560130-42-9 represents a key component in the global fight against resistant bacterial infections.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient (API) in injectable antibiotic formulations.
• Antibacterial Drug Development: Critical raw material for R&D into new antibacterial therapies targeting resistant organisms.
• Complicated Skin Infection Treatment: Used in the manufacture of drugs indicated for complicated skin and skin structure infections (cSSSI).
• Hospital-Acquired Pneumonia Treatment: Key component in medications for hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP).
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in laboratories.
• Microbiological Research: Used in in-vitro studies to investigate mechanisms of action and resistance against Gram-positive bacteria.

Basic Information

Product Name	Telavancin Hydrochloride
CAS No.	560130-42-9
Molecular Formula	C80H106Cl2N11O27P • xHCl
Molecular Weight	1755.6 g/mol (base)
Synonyms	Telavancin HCl; TD-6424; (9S,11S,14S,32R,33S,35S,38S,42S)-33-[[2-(Decylamino)ethyl]phosphono]-11-[(1R)-1-hydroxyethyl]-14,35-dimethoxy-3,12,15,24,30,32,33,34,35,36,37,38,39,40,41,42,43,44-octadecahydro-9,42-dihydroxy-3,15,24,30,38-pentamethyl-26,28-dioxo-2,5,8,13,16,19,22,25,28,31,34,37,40-tridecaoxa-1(2,3)-[1,3]thiazola-4(1,2)-benzenacyclooctatetradecaphane-14-carboxamide hydrochloride; VIBATIV (Brand Name); LY333328 (Research Code)
EINECS	Contact for details

Quality Control

Our Telavancin Hydrochloride is manufactured under strict quality systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) is provided with each shipment, detailing compliance with relevant specifications. We support compliance with cGMP, ICH guidelines, and major pharmacopoeial standards (USP/EP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Bacterial Endotoxins	< 0.5 EU/mg (for injectable grade)
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.