Description

4-Bromo-2-(Difluoromethoxy)Benzoic Acid is a high-purity, synthetically valuable benzoic acid derivative distinguished by its bromine and difluoromethoxy substituents. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the introduction of specific functional groups essential for developing active molecules. It is primarily required by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, where the difluoromethoxy group can influence bioavailability and stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers or functional units for advanced polymers and liquid crystals.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological mechanisms.
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring specific, complex benzoic acid derivatives.

Basic Information

Product Name	4-Bromo-2-(Difluoromethoxy)Benzoic Acid
CAS No.	553672-25-6
Molecular Formula	C8H5BrF2O3
Molecular Weight	267.03 g/mol
Synonyms	2-(Difluoromethoxy)-4-bromobenzoic acid; 4-Bromo-2-(difluoromethoxy)benzoic acid; Benzoic acid, 4-bromo-2-(difluoromethoxy)-; 4-Bromo-2-difluoromethoxybenzoic acid; 553672-25-6; 4-Br-2-(CF2O)PhCOOH
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethoxy)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.