Description

2-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, imparts desirable electronic and steric properties to target molecules, making it essential for developing novel compounds with enhanced performance. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, as well as by material scientists exploring advanced functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, oncology, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic semiconductors, liquid crystal compounds, and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed in academic and industrial R&D labs as a versatile reagent for Suzuki-Miyaura coupling, Heck reactions, and other cross-coupling methodologies.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.
• Advanced Polymer Modification: Can be incorporated into polymer backbones to create specialty polymers with tailored thermal, optical, or surface properties.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethyl)Cinnamic Acid
CAS No.	545393-87-1
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[2-Fluoro-4-(trifluoromethyl)phenyl]acrylic acid; 2-Fluoro-4-(trifluoromethyl)cinnamic acid; (2E)-3-[2-Fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid; trans-2-Fluoro-4-(trifluoromethyl)cinnamic acid; α-Fluoro-β-[2-fluoro-4-(trifluoromethyl)phenyl]acrylic acid; FTCA; 2-F-4-TFMCA
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.