Description

n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-2,3-Dihydro-1,4-Benzodioxin-6-Carboxamide Fumarate is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This substance matters as a key intermediate or active pharmaceutical ingredient (API) for investigating novel therapeutic agents targeting the central nervous system. Pharmaceutical companies, biotechnology firms, and advanced contract research organizations (CROs) require this material for preclinical studies, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Research: Used as a reference standard or as the active component in formulation studies for new chemical entities (NCEs).
• Neuroscience Research: Applied in in vitro and in vivo studies to investigate mechanisms related to specific receptor interactions.
• Process Chemistry Development: Utilized for scaling up synthetic routes, optimizing yield, and establishing robust manufacturing processes under GMP guidelines.
• Analytical Standard: Provides a high-purity benchmark for developing and validating HPLC, LC-MS, and other analytical methods for quality control.
• Preclinical Toxicology Studies: Employed in safety and efficacy assessments required for regulatory submissions (e.g., IND/NDA).

Basic Information

Product Name	n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-2,3-Dihydro-1,4-Benzodioxin-6-Carboxamide Fumarate
CAS No.	527680-56-4
Molecular Formula	C20H24N2O6 • C4H4O4
Molecular Weight	528.51 g/mol (for the fumarate salt)
Synonyms	(R)-6-((3-Quinuclidinyl)carbamoyl)-2,3-dihydro-1,4-benzodioxine fumarate; (R)-QNB Fumarate; (R)-Quinuclidinyl Benzodioxine Carboxamide Fumarate; (3R)-Quinuclidin-3-yl 2,3-dihydro-1,4-benzodioxine-6-carboxamide fumarate; (R)-QCA Fumarate; 527680-56-4; UNII-6F8Z1V4K6F
EINECS	Contact for details

Quality Control

Our n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-2,3-Dihydro-1,4-Benzodioxin-6-Carboxamide Fumarate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as chiral purity, assay, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0% w/w
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.