Description

2-Fluoro-5-Nitro-Benzoic Acid tert-Butyl Ester is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the life sciences sector for constructing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the nitro and fluoro substituents confer specific biological activity.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials due to its specific electronic properties.
• Cross-Coupling Reactions: The aromatic fluoride and ester groups make it a suitable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Peptidomimetics & Bio-conjugation: The tert-butyl ester protecting group is valuable in peptide synthesis and for creating cleavable linkers in bioconjugation chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	2-Fluoro-5-Nitro-Benzoic Acid tert-Butyl Ester
CAS No.	526218-22-4
Molecular Formula	C₁₁H₁₂FNO₄
Molecular Weight	241.22 g/mol
Synonyms	tert-Butyl 2-fluoro-5-nitrobenzoate; 2-Fluoro-5-nitrobenzoic acid tert-butyl ester; Benzoic acid, 2-fluoro-5-nitro-, 1,1-dimethylethyl ester; 5-Nitro-2-fluorobenzoic acid tert-butyl ester; 2-Fluoro-5-nitro-benzoic acid t-butyl ester; t-Butyl 2-fluoro-5-nitrobenzoate; 526218-22-4
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitro-Benzoic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.