Description

[1,1'-Biphenyl]-4-Carboxylic Acid, 3,5-Difluoro- is a high-purity, fluorinated biphenyl derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the precise electronic and steric properties imparted by the difluoro substitution on the biphenyl scaffold, enabling the synthesis of complex molecules with tailored functionalities. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorinated biphenyl core enhances biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials in display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve thermal stability, chemical resistance, and optical properties.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create sophisticated ligands for asymmetric catalysis and cross-coupling reactions.
• Academic & Industrial R&D: A valuable reagent for exploratory synthetic chemistry in university laboratories and corporate R&D centers.

Basic Information

Product Name	[1,1'-Biphenyl]-4-Carboxylic Acid, 3,5-Difluoro-
CAS No.	505083-02-3
Molecular Formula	C13H8F2O2
Molecular Weight	234.20 g/mol
Synonyms	3,5-Difluoro[1,1'-biphenyl]-4-carboxylic acid; 3,5-Difluoro-4'-carboxybiphenyl; 4-Biphenylcarboxylic acid, 3,5-difluoro-; 3,5-Difluorobiphenyl-4-carboxylic acid; Biphenyl-4-carboxylic acid, 3,5-difluoro-; 4'-Carboxy-3,5-difluorobiphenyl; 3,5-Difluoro-4-phenylbenzoic acid
EINECS	Contact for details

Quality Control

Our production of [1,1'-Biphenyl]-4-Carboxylic Acid, 3,5-Difluoro- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity and quantify impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.