Description

3',4'-Difluoro-Biphenyl-4-Carboxylic Acid is a high-purity fluorinated biphenyl derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates fluorine atoms to modulate electronic properties and enhance metabolic stability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides where the difluorobiphenyl scaffold contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a core component or intermediate in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials for electronic displays.
• Polymer & Material Science: Acts as a monomer or functional additive for creating high-performance polymers with specific thermal, optical, or chemical resistance properties.
• Chemical Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Heck) and other organic transformations to construct complex, fluorinated aromatic systems.

Basic Information

Product Name	3',4'-Difluoro-Biphenyl-4-Carboxylic Acid
CAS No.	505082-81-5
Molecular Formula	C13H8F2O2
Molecular Weight	234.20 g/mol
Synonyms	[4-(3,4-Difluorophenyl)]benzoic Acid; 4'-(3,4-Difluorophenyl)-[1,1'-biphenyl]-4-carboxylic Acid; 3,4-Difluoro-4'-carboxybiphenyl; 4-Biphenylcarboxylic Acid, 3',4'-difluoro-; 3',4'-Difluoro[1,1'-biphenyl]-4-carboxylic Acid; 4-Carboxy-3',4'-difluorobiphenyl
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-Biphenyl-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.