Description

6-(2,4-Difluorophenyl)-Nicotinic Acid is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which introduces both a nicotinic acid moiety and difluorophenyl group into target molecules, enabling the development of compounds with enhanced biological activity and metabolic stability. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity and target binding.
• Ligand and Catalyst Development: Serves as a precursor for constructing complex ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials that require fluorinated aromatic components.
• Chemical Biology Probes: Utilized as a building block for creating fluorescent tags or molecular probes to study biological processes.
• Custom Synthesis and Scale-up: Supplied for contract research organizations (CROs) and CDMOs for custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	6-(2,4-Difluorophenyl)-Nicotinic Acid
CAS No.	505082-74-6
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	2,4-Difluoro-6-pyridinecarboxylic acid phenyl derivative; 6-(2,4-Difluorophenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-(2,4-difluorophenyl)-; Nicotinic acid, 6-(2,4-difluorophenyl)-; 505082-74-6; 2,4-Difluorophenylnicotinic Acid
EINECS	Contact for details

Quality Control

Every batch of 6-(2,4-Difluorophenyl)-Nicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide full traceability and guarantee high chemical purity suitable for research and development applications. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is supplied with each shipment to ensure compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.